Gut Connections

Gut Health and Hormones: The Hidden Connection

Learn how your gut microbiome influences hormone balance and what you can do to support both.

ElenaNovember 20259 min read
Gut Health and Hormones: The Hidden Connection

Hormonal imbalances are incredibly common, affecting everything from mood and energy to weight and fertility. What many people don't realise is that the gut plays a central role in hormone production, metabolism, and elimination. Understanding this connection opens up new possibilities for addressing hormonal issues at their root.

The Estrobolome: Your Gut's Hormone Regulator

One of the most important discoveries in gut-hormone research is the estrobolome — a collection of gut bacteria that metabolise oestrogen. These bacteria produce an enzyme called beta-glucuronidase, which influences how much oestrogen is eliminated from the body versus reabsorbed.

When the estrobolome is balanced:

  • Oestrogen is properly metabolised and eliminated
  • Hormone levels remain stable
  • Symptoms of oestrogen dominance are minimised
  • When the estrobolome is imbalanced:

  • Oestrogen may be reabsorbed instead of eliminated
  • This can lead to oestrogen dominance
  • Symptoms like PMS, heavy periods, and hormonal acne may worsen
  • How Gut Health Affects Different Hormones

    Oestrogen

    As mentioned, the gut directly influences oestrogen levels through the estrobolome. Gut dysbiosis can lead to either oestrogen excess (if too much is reabsorbed) or oestrogen deficiency (if it's eliminated too quickly).

    Thyroid Hormones

    Your gut plays a crucial role in thyroid function:

  • About 20% of T4 to T3 conversion happens in the gut
  • Gut bacteria influence this conversion process
  • Intestinal inflammation can impair thyroid hormone activation
  • Gut issues often coexist with thyroid conditions
  • Cortisol

    The gut-brain axis means that gut health directly impacts stress hormone regulation:

  • Gut inflammation can trigger cortisol release
  • Chronic stress alters gut bacteria composition
  • Dysbiosis can perpetuate the stress response
  • Insulin

    Your gut bacteria influence blood sugar regulation and insulin sensitivity:

  • Certain bacteria improve insulin sensitivity
  • Gut inflammation can contribute to insulin resistance
  • The gut microbiome affects how we extract calories from food
  • Signs Your Hormones May Be Affected by Gut Issues

  • PMS symptoms that worsen with digestive issues
  • Hormonal acne that doesn't respond to topical treatments
  • Thyroid medication that doesn't seem to work optimally
  • Weight gain concentrated around the midsection
  • Mood swings that correlate with digestive symptoms
  • Fertility challenges alongside gut problems
  • Supporting Hormone Balance Through Gut Health

    Balance the estrobolome Eating plenty of fibre supports healthy oestrogen elimination. Cruciferous vegetables are particularly beneficial.

    Reduce gut inflammation Inflammation anywhere in the body affects hormone balance. Identifying and removing gut irritants is crucial.

    Support liver function Your liver processes hormones for elimination. When the gut is unhealthy, liver function is often compromised.

    Address dysbiosis Testing can identify specific bacterial imbalances affecting hormone metabolism.

    Manage blood sugar Stable blood sugar supports healthy cortisol and insulin levels, which in turn affect other hormones.

    The Importance of Testing

    If you suspect gut issues are affecting your hormones, comprehensive testing can provide answers:

  • Stool testing to assess gut bacteria and inflammation
  • Hormone testing to identify specific imbalances
  • Blood sugar and insulin testing
  • Thyroid panel including T3, T4, and antibodies
  • The Bottom Line

    Hormonal health and gut health are intimately connected. If you've been struggling with hormonal symptoms despite conventional treatments, addressing your gut health may be the missing piece. A functional approach that considers both systems together often yields the best results.

    Ready to optimise your gut health?

    Book a free discovery call to discuss your symptoms and find out how personalised gut health support can help you.